2025 Annual Report
Annual Report
ECETOC publishes a framework for the risk assessment of plastic additives
Press Release

ECETOC publishes a framework for the risk assessment of plastic additives

Part 1 sets out the fundamental elements, from problem formulation to risk characterisation.Brussels, 22 July 2026. The ECETOC Plastic Additives Task Force has published the first of two peer...
January 2026 news from the Sec Gen
News

January 2026 news from the Sec Gen

Dear colleagues and friends,As we begin a new year, I would like to thank you for your continued engagement and trust in ECETOC. 2026 promises to be an exciting and dynamic year, and I am pleased...
HSSD Tool

HSSD Tool

This software was developed by a consortium of partners to facilitate the uptake of novel approaches to estimate aquatic threshold concentrations (e.g. the concentration at which 5% of the species are exposed above their EC50, HC5).
The Human Exposure Assessment Tools Database (heatDB)

The Human Exposure Assessment Tools Database (heatDB)

heatdb is a public directory of exposure data sources as well as available tools for exposure
NanoApp

NanoApp

ECETOC’s NanoApp is a tool designed to define the boundaries of sets of similar nanoforms and to generate a justification for the REACH registration.
Targeted Risk Assessment (TRA)

Targeted Risk Assessment (TRA)

The Targeted Risk Assessment (TRA) estimates exposures to workers, consumers and the environment that arise during a series of events.
TRA Task Force – Worker branch

TRA Task Force – Worker branch

Why? The Worker TRA Task Force has been active since 2019, delivering projects that advance the scientific basis of the Worker Targeted Risk Assessment (TRA) tool. Its overarching objective is to e...
Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Immunotoxicity assessment: Addressing Challenges and Advancing Methodologies [Workshop → Task Force]​

Why?Regulatory assessment of immunotoxic properties of chemicals is a complex and challenging task​ Limited regulatory guidance exists​ Lack of industry and regulatory knowledge​...
Chronic fish case studies towards an IATA

Chronic fish case studies towards an IATA

Why?Hazard and safety assessments for the pelagic compartment often rely on in vivo studies using a single fish species, raising ethical concerns and uncertainty in terms of extrapolation....

Immunotoxicity-NeurotoxicityCytokine signaling

Publications

Workshop Report 33: Chemical respiratory allergy: clinical information and how to use it and improve it. October 27-28 October 2016, Madrid
Workshop Report

Workshop Report 33: Chemical respiratory allergy: clinical information and how to use it and improve it. October 27-28 October 2016, Madrid

The workshop identified various areas that can drive improvements in the identification, classification and risk characterisation of respiratory sensitisers and recommended several practical steps to...
Thresholds in chemical respiratory sensitisation
Article

Thresholds in chemical respiratory sensitisation

Brussels, May 2015 A variety of chemicals are known to cause allergic sensitisation of the respiratory tract associated with allergic rhinitis and asthma. It is generally accepted that the development...
TR 122 – Poorly Soluble Particles / Lung Overload
Technical Report

TR 122 – Poorly Soluble Particles / Lung Overload

SCIENCE NEWS FLASH: New ECETOC report addresses poorly soluble particles and lung overload  Brussels, January 2014 Despite being regarded as biologically inert, many poorly soluble substan...
Workshop Report

Workshop Report 06 – Workshop on Chemical Pollution, Respiratory Allergy and Asthma

WR 06 : Workshop on Chemical Pollution, Respiratory Allergy and Asthma | February 2006Atopic allergy and asthma remain important health issues. It is therefore of significance that in more moderni...
Technical Report

TR 095 Vol II – The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume II – Substance Profiles

TR 095 Vol II : The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume II - Substance Profiles | March 2005 This report provides an update of an earlier ECETOC reviewa<...
Technical Report

TR 095 Vol I – The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume I

TR 095 Vol I : The Toxicology of Glycol Ethers and its Relevance to Man (Fourth Edition) Volume I | March 2005 This report provides an update of an earlier ECETOC reviewa of a number of im...
Technical Report

TR 081 – Human Acute Intoxication from Monochloroacetic Acid: Proposals for Therapy

TR 081 : Human Acute Intoxication from Monochloroacetic Acid: Proposals for Therapy | November 2001 The industrial chemical monochloroacetic acid (MCAA) is used mainly in carboxylation reactions. It...
Technical Report

TR 075 – Organophosphorus Pesticides and Long-term Effects on the Nervous System

TR 075 : Organophosphorus Pesticides and Long-term Effects on the Nervous System | December 1998 Organophosphorus pesticides (OPps) have been used for decades. In view of their potent biological effe...

Task Forces

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Case Studies on Reliability and Relevance Considerations during Validation of NAMs

Why?Validation of NAMs is often overlooked despite its importance for regulatory use. Traditional validation methods are less suitable for NAMs, which focus on key events rather than apical...